METHOD FOR SELECTIVELY REMOVING HALOGEN

PURPOSE:To provide a method for profitably producing a 1,2-cis-2- fluorocyclopropanecarboxylic acid derivative useful as a raw material for producing a quinolone derivative which is an excellent antimicrobial agent. CONSTITUTION:A compound of formula I or formula II (R is H, a 1-4C alkyl; X is Cl, B...

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Bibliographic Details
Main Authors IKETANI TAKANOBU, YUKIMOTO YUSUKE, EHATA TSUTOMU, KANBARA SHINJI, KAWANISHI HIROFUMI, AKIBA TOSHIFUMI
Format Patent
LanguageEnglish
Published 11.04.1995
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To provide a method for profitably producing a 1,2-cis-2- fluorocyclopropanecarboxylic acid derivative useful as a raw material for producing a quinolone derivative which is an excellent antimicrobial agent. CONSTITUTION:A compound of formula I or formula II (R is H, a 1-4C alkyl; X is Cl, Br) is subjected to a catalytic hydrocracking reaction in the presence of a base, preferably 1,2-diaminoethane, to obtain a compound of formula III. The catalytic hydrocracking reaction is carried out by treating a reaction substrate in the presence of a catalyst selected from various metal catalysts (preferably Raney nickel or PdC) in a solution under a hydrogen gas atmosphere having a hydrogen gas pressure of 1-50atm. The reaction advances a dehalogenation reaction in a steric configuration-holding state, thus enabling to obtain 1,2-cis-fluorocyclopropanecarboxylic acid derivative in a good yield.
Bibliography:Application Number: JP19940183173