THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS

PURPOSE:To provide a therapeutic agent and/or preventive agent esp. for atherosclerosis, containing, as the active ingredient, a thiazolidine derivative having activity to suppress oxidation/peroxidation of low-density lipoproteins. CONSTITUTION:The therapeutic agent and/or preventive agent for arte...

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Bibliographic Details
Main Authors IWAOKA SADAKI, TABATA FUMIKO, SAKU KEIJIROU, KOGA TEIICHIRO, YOSHIOKA TAKAO
Format Patent
LanguageEnglish
Published 10.02.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:To provide a therapeutic agent and/or preventive agent esp. for atherosclerosis, containing, as the active ingredient, a thiazolidine derivative having activity to suppress oxidation/peroxidation of low-density lipoproteins. CONSTITUTION:The therapeutic agent and/or preventive agent for arteriosclerosis containing as the active ingredient, a compound of the formula [R , R , R and R are each H or lower alkyl; R is H, an aliphatic acyl, (substituted) aromatic acyl or lower alkoxycarbonyl) or a pharmacologically permissible salt thereof, e.g. 5-[4-(6-hydroxy-2,5,7,8-tetramethylcoumarone-2-methoxy)benzyl] thiazolidine-2,4-dione. This compound can be administered orally or parenterally, its dose being normally 50-5000mg a day per adult.
Bibliography:Application Number: JP19940024184