5-ALKOXY-3-ISOXAZOLIDINONE, ITS PRODUCTION AND USE THEREOF

PURPOSE:To obtain the subject new compound useful as an intermediate for a medicine, an agrochemlcal, etc. CONSTITUTION:A compound of the formula (R is a lower alkoxyl) such as 5-methoxy-3-isoxazolidinone. The compound is obtained by reacting a 3-lower alkoxyacrylic acid lower alkyl ester with hydro...

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Bibliographic Details
Main Authors SOEJIMA TADASHI, SHIMURA KAZUHIKO
Format Patent
LanguageEnglish
Published 19.12.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To obtain the subject new compound useful as an intermediate for a medicine, an agrochemlcal, etc. CONSTITUTION:A compound of the formula (R is a lower alkoxyl) such as 5-methoxy-3-isoxazolidinone. The compound is obtained by reacting a 3-lower alkoxyacrylic acid lower alkyl ester with hydroxylamine in water, a lower alcohol or a mixed solvent of water and the lower alcohol in the presence of an alkali metal hydroxide at -20 to 50 deg.C and then treated with an acid (e.g. hydrochloric acid). Further, an alcohol is removed from the compound of the formula in water, a lower alcohol or a mixed solvent of water and the lower alcohol in the presence of an alkali metal hydroxide and the resultant substance is treated with an acid to readily give 3-hydroxyisoxazole useful as a synthetic intermediate for a medicine, an agrochemical, etc., in high yield.
Bibliography:Application Number: JP19940119855