PRODUCTION OF CHLOROHYDRIN DERIVATIVE

PURPOSE:To obtain the subject compound useful as, e.g. a raw material for oxirane compounds in a high yield from an easy-to-handle raw material, by reaction of chloroacetaldehyde with a Grignard reagent. CONSTITUTION:This chlorohydrin derivative of the formula is obtained by reaction between chloroa...

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Bibliographic Details
Main Author GEJITOUSHIYO HIROSHI
Format Patent
LanguageEnglish
Published 12.12.1995
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To obtain the subject compound useful as, e.g. a raw material for oxirane compounds in a high yield from an easy-to-handle raw material, by reaction of chloroacetaldehyde with a Grignard reagent. CONSTITUTION:This chlorohydrin derivative of the formula is obtained by reaction between chloroacetaldehyde of formula 3ClCH2CHO and a Grignard reagent of formula RMgX (R is an aryl or pyridyl; X is a halogen) in a solvent (e.g. THF) at 20-100 deg.C. The chloroacetaldehyde can be obtained by distillation of a commercially available aqueous chloroacetaldehyde solution or acid- catalyzed thermal decomposition of chloroacetaldehyde trimer. This chlorohydrin derivative is also important as an intermediate convertible to various compounds.
Bibliography:Application Number: JP19940140852