PRODUCTION OF AMINOMETHYLPYRIDINE DERIVATIVE AND INTERMEDIATE THEREFOR

PURPOSE:To efficiently obtain the subject compound useful as a synthetic intermediate for insecticides and acaricides by reacting a pyridine derivative having a specific structure with aqueous ammonia in the presence of a compound having formyl group and a phase-transfer catalyst and then hydrolyzin...

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Bibliographic Details
Main Authors MIYAZAKI TOMONORI, MAEJIMA CHIKA
Format Patent
LanguageEnglish
Published 25.07.1995
Edition6
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To efficiently obtain the subject compound useful as a synthetic intermediate for insecticides and acaricides by reacting a pyridine derivative having a specific structure with aqueous ammonia in the presence of a compound having formyl group and a phase-transfer catalyst and then hydrolyzing the resultant compound. CONSTITUTION:This method for producing an aminomethylpyridine derivative expressed by formula V (X is H or a halogen) is to react (A) a pyridine derivative expressed by formula I (X is a halogen) with (B) aqueous ammonia in the presence of (C) a compound, containing formyl group and expressed by formula II (R is an aryl, a heterocyclic residue containing oxygen or a lower alkyl) and (D) a phase-transfer catalyst, provide an azomethine compound expressed by formula III [preferably a new azomethine compound expressed by formula IV (X is H or a halogen; R is an aryl or a heterocyclic residue containing oxygen)] and then hydrolyze the resultant compound. Furthermore, e.g. 3-(N-benzylideneaminomethyl)pyridine is cited as the azomethine compound expressed by formula IV and, e.g. 2-chloro-5-aminomethylpyridine is cited as the compound expressed by formula V.
Bibliography:Application Number: JP19930348239