PIPERAZINE UNSATURATED FATTY ACID DERIVATIVE

PURPOSE:To provide a new low toxic compound excellent in antiallergic effect and antiasthmatic effect in spite of its weak antihistaminic action and useful as a preventive and therapeutic agent for allergic diseases and asthma. CONSTITUTION:A compound of the formula [R1 is H, a 1 to 4C alkyl, a 1 to...

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Main Authors NAGAI HIROICHI, IWAKURA BUNGETSU, SAKAMOTO HIROHIKO, AKIMOTO YOSHINOBU, TAKENO TAKESHI, BONSHIHARA YASUKO, MUNEDA YASUJI, EDA SHOEI, OOTA YOUICHIROU, SAKURAI TOSHIMI, KAWANISHI KENJI, IMAHORI HIDEKAZU, KUKI MASAKATSU
Format Patent
LanguageEnglish
Published 30.05.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:To provide a new low toxic compound excellent in antiallergic effect and antiasthmatic effect in spite of its weak antihistaminic action and useful as a preventive and therapeutic agent for allergic diseases and asthma. CONSTITUTION:A compound of the formula [R1 is H, a 1 to 4C alkyl, a 1 to 4C alkoxy, a halogen, CF3, NO2, NH2 or NHCOCH3; R2 is OH, a 1 to 8C alkoxy, a 3 to 6C cycloalkyl-a 1 to 4C alkoxy, a 3 to 6C cycloalkoxy, a 1 to 4C alkyloxy-a 1 to 4C alkoxy, a 1 to 4C hydroxyalkoxy, ethoxycarbonylamino, etc.; A is phenyl, 1- or 2-naphthyl, 2-thienyl or 2-pyridyl; Y is a 3 to 6C alkylene having one or more double or triple bonds or CH2CR4=CH (R4 is an alkoxy n is 0 to 3], e.g. ethyl 4-[4[(4-chlorohenyl)phenylmethyl]-1-piperazinyl]-2-butenoate dihydrochloride.
Bibliography:Application Number: JP19930283111