PRODUCTION OF SODIUM 3R,5S-(+)-ERYTHRO-(E)-7- (4-(4-FLUOROPHENYL)-2,6-DIISOPROPYL-5-METHOXYMETHYL- PYRID-3-YL)-3,5-DIHYDROXYHEPT-6-ENOATE

Enantiomerically pure 3R,5S-(+)-sodium erythro-(E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxymethylpyrid -3-yl]-3,5-dihydroxy-hept-6-enoate is prepared by first cyclising a corresponding racemic ester to give the racemic lactones and subsequently separating these chromatographically by means of...

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Bibliographic Details
Main Authors RORUFU ANGAABAUAA, BERUNAA HINSUKEN, RORUFU GUROSAA, YOAHIMU REEZE
Format Patent
LanguageEnglish
Published 22.11.1994
Edition5
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Enantiomerically pure 3R,5S-(+)-sodium erythro-(E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxymethylpyrid -3-yl]-3,5-dihydroxy-hept-6-enoate is prepared by first cyclising a corresponding racemic ester to give the racemic lactones and subsequently separating these chromatographically by means of a chiral stationary phase. Cleavage of the enantiomerically pure lactones by means of base gives the enantiomerically pure end products.
Bibliography:Application Number: JP19940072787