BICYCLIC COMPOUND, ITS PRODUCTION AND MEDICAL COMPOSITION CONTAINING THE SAME COMPOUND

• Main Authors: AOKI SATOSHI, SHIRAI FUMIYUKI, CHIBA TOSHIYUKI, SAKURAI MINORU, MATSUDA KEIJI
• Format: Patent
• Language: English
• Published: 20.09.1994
• Edition: 5
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

PURPOSE:To obtain a new 3-pyrrolidinylthio-1-azabicyclo [3.2.0.]hept-2-ene-2- carboxylic acid compound useful as an antimicrobial agent. CONSTITUTION:A compound of formula I [R is a (protected) carboxyl group; R is a (protected) hydroxyloweralkyl; R is H or a lower alkyl; In relation to R and R , R is a lower alkyl and R is a lower alkyl or a hydroxyloweralkyl. or, R is a lower alkyl, lower alkenyl, 2-hydroxyethyl, etc., and R is H or an imino-protecting group; R is H or an imino-protecting group; A is a lower alkylene provided that A is ehylene in the case R is carbamoylmethyl, etc.], eg. (2R,4S)-1-allyloxycarbonyl-2-[2-(N,N-dimethylamino) ethyl]-4-triphenylmethylthiopyrrolidine. The compound of formula I is synthesized by reacting a compound of formula II with a compound of formula III.