PHYSIOLOGICALLY ACTIVE SUBSTANCE BR-011

PURPOSE:To provide a new physilogically active substance BR-011 having excellent suppressive activity on bone resorption, thus useful as a medicine for the diseases due to bone dysbolism such as osteoporosis and hypercalcemia, produced by a certain kind of strain. CONSTITUTION:The physiologically ac...

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Bibliographic Details
Main Authors ISOGAI KAZUHIDE, MAEJIMA AKIKO, ONO JUNKO, KAGAMIZONO TERUMI, HANADA KAZUNORI
Format Patent
LanguageEnglish
Published 26.07.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:To provide a new physilogically active substance BR-011 having excellent suppressive activity on bone resorption, thus useful as a medicine for the diseases due to bone dysbolism such as osteoporosis and hypercalcemia, produced by a certain kind of strain. CONSTITUTION:The physiologically active substance BR-011, a compound of the formula, which can be obtained by culture of a strain, Stachybotrys sp. TF-0372 (FERM P-13323); in this case, the optimal condition for the medium is: pH3-5, 24-31 deg.C. This compound is a low-molecular weight one, and can be taken.
Bibliography:Application Number: JP19920345018