PRODUCTION OF OPTICALLY ACTIVE ALPHA-METHYLBENZYLAMINE

PURPOSE:To obtain a compound by using optically active mandelic acid as a resolving agent and adding bis(alpha-methylbenzyl)amine and salts to a reactional system and resolving (RS)-alpha-methylbenzylamine. CONSTITUTION:(RS)-alpha-Methylbenzylamine is made to react with optically active mandelic aci...

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Bibliographic Details
Main Authors SAKAI KENICHI, SAIGO KAZUHIKO, NOHIRA HIROYUKI, MURAKAMI NAOMICHI
Format Patent
LanguageEnglish
Published 11.01.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To obtain a compound by using optically active mandelic acid as a resolving agent and adding bis(alpha-methylbenzyl)amine and salts to a reactional system and resolving (RS)-alpha-methylbenzylamine. CONSTITUTION:(RS)-alpha-Methylbenzylamine is made to react with optically active mandelic acid in the presence of a bis(alpha-methylbenzyl)amine of formula I (* indicates asymmetric carbon) and a salt of ammonia or a primary amine with an inorganic acid or an organic acid (e.g. ammonium chloride) and/or water-soluble inorganic salts (e.g. potassium nitrate) in an aqueous medium to afford the objective sparingly soluble optically active diastereomer salt of formula II. Since a crystal of the deposited sparingly soluble diastereomer salt is obtained as a thick hexagonal platy crystal or a rhombic crystal good in filtrability, the product of high optical purity can readily be produced.
Bibliography:Application Number: JP19920158356