NEW CYCLIC PEPTIDE COMPOUND AND ITS PRODUCTION
PURPOSE:To provide a new compound having excellent inhibiting action on elastase originated from human leukocyte and, accordingly, useful as an elastase- inhibition agent for the treatment or prevention of pulmonary emphysema, respiratory distress syndrome and inflammatory diseases such as rheumatoi...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English |
Published |
21.06.1994
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Edition | 5 |
Subjects | |
Online Access | Get full text |
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Abstract | PURPOSE:To provide a new compound having excellent inhibiting action on elastase originated from human leukocyte and, accordingly, useful as an elastase- inhibition agent for the treatment or prevention of pulmonary emphysema, respiratory distress syndrome and inflammatory diseases such as rheumatoid arthritis and bronchitis. CONSTITUTION:The new compound of formula I or II (R is benzylcarbonyl or isovaleryl; R and R are OH or together form carbonyl oxygen), e.g. Q17897-A of formula III. It has a molecular weight of 934 and molecular formula of C46H62N8O13. It can be produced by culturing a microbial strain belonging to Flexibacter and capable of producing the compound of formula I or formula II [e.g. new Flexibacter sp.Q17897 (FERM P-13305)] and subjecting the cultured product to conventional extraction, separation and purification processes. The cultivation is preferably carried out under aeration and agitation at 27 deg.C and pH 6-8. |
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AbstractList | PURPOSE:To provide a new compound having excellent inhibiting action on elastase originated from human leukocyte and, accordingly, useful as an elastase- inhibition agent for the treatment or prevention of pulmonary emphysema, respiratory distress syndrome and inflammatory diseases such as rheumatoid arthritis and bronchitis. CONSTITUTION:The new compound of formula I or II (R is benzylcarbonyl or isovaleryl; R and R are OH or together form carbonyl oxygen), e.g. Q17897-A of formula III. It has a molecular weight of 934 and molecular formula of C46H62N8O13. It can be produced by culturing a microbial strain belonging to Flexibacter and capable of producing the compound of formula I or formula II [e.g. new Flexibacter sp.Q17897 (FERM P-13305)] and subjecting the cultured product to conventional extraction, separation and purification processes. The cultivation is preferably carried out under aeration and agitation at 27 deg.C and pH 6-8. |
Author | YASUMURO KENICHI SUZUKI KENICHI IMAI YOSHIMITSU TERAMURA KYOKO SHIBAZAKI MITSUJI SUZUKI YASUTO ABE KENJI |
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RelatedCompanies | YAMANOUCHI PHARMACEUT CO LTD |
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Snippet | PURPOSE:To provide a new compound having excellent inhibiting action on elastase originated from human leukocyte and, accordingly, useful as an elastase-... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
Title | NEW CYCLIC PEPTIDE COMPOUND AND ITS PRODUCTION |
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