NEW CYCLIC PEPTIDE COMPOUND AND ITS PRODUCTION

• Main Authors: TERAMURA KYOKO, SUZUKI YASUTO, SHIBAZAKI MITSUJI, ABE KENJI, SUZUKI KENICHI, YASUMURO KENICHI, IMAI YOSHIMITSU
• Format: Patent
• Language: English
• Published: 21.06.1994
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PURPOSE:To provide a new compound having excellent inhibiting action on elastase originated from human leukocyte and, accordingly, useful as an elastase- inhibition agent for the treatment or prevention of pulmonary emphysema, respiratory distress syndrome and inflammatory diseases such as rheumatoid arthritis and bronchitis. CONSTITUTION:The new compound of formula I or II (R is benzylcarbonyl or isovaleryl; R and R are OH or together form carbonyl oxygen), e.g. Q17897-A of formula III. It has a molecular weight of 934 and molecular formula of C46H62N8O13. It can be produced by culturing a microbial strain belonging to Flexibacter and capable of producing the compound of formula I or formula II [e.g. new Flexibacter sp.Q17897 (FERM P-13305)] and subjecting the cultured product to conventional extraction, separation and purification processes. The cultivation is preferably carried out under aeration and agitation at 27 deg.C and pH 6-8.