PRODUCTION OF 3-ACYLAMINO-6-PHENYLOXY-7-ALKYL SULFONYLAMINO-4H-1-BENZOPYRAN-4-ONE OR ITS SALT

PURPOSE:To produce the subject compound useful as an antiinflammatory agent on an industrial scale in high yield with short steps by reacting a specific benzene derivative with a nitrile derivative or its salt and cyclizing the obtained compound. CONSTITUTION:The objective 3-acylamino-6-phenyloxy-7-...

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Bibliographic Details
Main Authors TAKENO TAKATSUNE, MOMOI KAISHU, NAGAKI HIDEYOSHI, INABA TAKIHIRO, YAMADA MINORU
Format Patent
LanguageEnglish
Published 20.04.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:To produce the subject compound useful as an antiinflammatory agent on an industrial scale in high yield with short steps by reacting a specific benzene derivative with a nitrile derivative or its salt and cyclizing the obtained compound. CONSTITUTION:The objective 3-acylamino-6-phenyloxy-7-alkylsulfonylamino-4H-1- benzopyran-4-one of formula 4 (e.g. 3-acetylamino-7-methylsulfonylamino-6- phenoxy-4H-1-benzopyran-4-one) can be produced by reacting a benzene derivative of formula 1 (R is phenyl which may be substituted with halogen; R is lower alkyl; R is H or lower alkyl) with a nitrile derivative of formula 2 (R is H or acyl which may be substituted with halogen) (e.g. aminoacetonitrile) or its salt to get a compound of formula 3 or its salt and cyclizing the obtained compound.
Bibliography:Application Number: JP19910292067