PRODUCTION OF (S)-2-(4-CHLOROPHENYL) 3-METHYLBUTYRATE

• Main Authors: KUMAGAI KAZUO, MASUTOMO SHIYUNICHI, MURAI RIKA, MITSUTA MASARU
• Format: Patent
• Language: English
• Published: 07.09.1993
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

PURPOSE:To produce the subject compound of high optical purity useful as a raw material of an insecticide in a high yield by allowing a microorganism belonging to Pseudomonas to react on (chlorophenyl)-methyl butyronitrile. CONSTITUTION:The objective compound of formula III is obtained by allowing a microorganism [preferably Pseudomonas sp. B21C9 strain (FERMBP-3737)] belonging to Pseudomonas to react on 2-(4-chlorophenyl)-3-methylbutyronitrile of formula I or 2-(4-chlorophenyl)-3-methylbutylamide of formula II. The above- mentioned reaction is carried out with stirring preferably at pH 6 to 9 and at 20 to 40 deg.C. The reaction time is recommendably 1 to 40hr in general.