CYCLIC DEPSIPEPTIDE AND PRODUCTION THEREOF

• Main Authors: UOTANI KAZUMICHI, KOYAMA MASAO, KUWATA MAKI, OKADA TADAAKI, TAKAGI MASAYUKI, SHIMIZU AKIRA, KUBOTA HIDETOSHI, SASAKI TORU
• Format: Patent
• Language: English
• Published: 09.07.1993
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PURPOSE:To provide a novel compound useful as an anthelminthic. CONSTITUTION:A cyclic depsipeptide PF1022B of the formula. The substance is obtained by a PF-1022B substance-producing microorganism in an aconidial imperfect fungus is aerobically cultured in a medium containing the nutrients which can be utilized by usual microorganisms, particularly by the submerged culture method and by extracting with solvents. The descriptions of the compound are as follows: color and properties: colorless powder; melting point: 83 to 85 deg.C; molecular formula: C64H84N4O12; elementary analyses: C 69.81%, H 7.64%, N 5.09% (calculated); specific rotation: [alpha]D25=-66 deg. (c=1.0 in MeOH); solubility: soluble in chloroform, acetone, ethyl acetate, methanol, dimethyl sulfoxide; insoluble in water; acidic, basic or neutral classification: neutral one.