NEW CEPHALOSPORIN DERIVATIVE

PURPOSE:To provide the subject compound having an excellent antibacterial activity and useful for the therapy of various bacterial infectious diseases. CONSTITUTION:A compound of formula I [R is H, (substrtuted) lower alkyl; R is H, ester-forming group capable of being readily cleaved with the ester...

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Bibliographic Details
Main Authors TAMURA ATSUSHI, TSUSHIMA MASAKI, SHIBAHARA MASAYUKI, IWAMATSU KATSUYOSHI
Format Patent
LanguageEnglish
Published 28.05.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:To provide the subject compound having an excellent antibacterial activity and useful for the therapy of various bacterial infectious diseases. CONSTITUTION:A compound of formula I [R is H, (substrtuted) lower alkyl; R is H, ester-forming group capable of being readily cleaved with the esterase of an digestive tract; R , R are H, halogen, etc.,] and its pharmaceutically acceptable salt. For example, 7-[(Z)-2-(2-aminothiazol-4-yl)-2- methoxyiminoacetoamide]-3-(benzothiazol-2-yl)thio-3-cephem-4-carboxylic acid. The compound of formula I is preferably obtained by reacting a compound of formula II (R is phenylacetyl, phenoxyacetyl, etc.; R is diphenylmethyl, benzyl, etc.,) with a compound of formula III, removing the protecting group from the obtained compound, reacting the reaction product with a compound of formula IV (R is amino-protecting group; R is substituted lower alkyl, oximeprotecting group) to acylate the 7-amino group, and subsequently removing the protecting group.
Bibliography:Application Number: JP19910226401