ANTITUMOR AGENT

PURPOSE:To provide a remarkable antitumor agent having high activity and low toxicity by compounding as an active ingredient an extract from the ink sack or ink of the Cephalopoda such as cuttlefish or octopus having been scarcely utilized. CONSTITUTION:An antitumor agent contains as a main ingredie...

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Main Authors SASAKI JINICHI, NARUMI FUMIAKI, OKUZAKI BUNICHI, HANAMATSU NORIMITSU, MATSUE HAJIME, UCHISAWA HIDEMITSU, TAKATANI YOSHIAKI, OKUBO OSAMU
Format Patent
LanguageEnglish
Published 24.03.1992
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:PURPOSE:To provide a remarkable antitumor agent having high activity and low toxicity by compounding as an active ingredient an extract from the ink sack or ink of the Cephalopoda such as cuttlefish or octopus having been scarcely utilized. CONSTITUTION:An antitumor agent contains as a main ingredient a heterosaccharide fraction containing proteoglycan as a main ingredient, the heterosaccharide fraction being prepared by extracting dry cuttlefish ink with water, buffer solution or a high salt solution containing guanine hydrochloride salt, urea, etc., or further subjecting the extract to an ion exchange gel column chromatography, molecular sieve treatment, etc., the dry cuttlefish ink being prepared by collecting ink sacks and ink from raw cuttlefish, octopus, etc., and subsequently dehydrating and drying the collected ink sacks and ink with an organic solvent such as acetone or ethanol. The antitumor agent is highly active, low toxic and effective for the treatment of cancers.
Bibliography:Application Number: JP19900209785