METHOD FOR PREPARING OPTICALLY ACTIVE TRICARBONYL CHROMIUM COMPLEX BY ENZYMATIC METHOD

• Main Authors: SHIRAKI MASARU, YAMAZAKI YUKINAE, HOSONO KUNIAKI
• Format: Patent
• Language: English
• Published: 06.03.1992
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; SPIRITS; VINEGAR; WINE

PURPOSE:To prepare the subject complex useful as a raw material for asymmetric organic synthesis reagents in a simple process in a good yield by asymmetrically acylating the racemates of a specific compound with a lipase and subsequently hydrolyzing the racemates. CONSTITUTION:The racemates of a compound of the formula I (R1 is alkyl, alkoxy) is asymmetrically acylated with a lipase, and the obtained ester is separated from the unreacted alcohol, followed by hydrolyzing the ester, whereby the dextro notatory optically active isomer and the levorotatory optically active isomer are obtained. The lipase is preferably a lipase originated from e.g. readily available Pseudomonas fluorescence.