METHOD FOR PREPARING OPTICALLY ACTIVE TRICARBONYL CHROMIUM COMPLEX BY ENZYMATIC METHOD

PURPOSE:To prepare the subject complex useful as a raw material for asymmetric organic synthesis reagents in a simple process in a good yield by asymmetrically acylating the racemates of a specific compound with a lipase and subsequently hydrolyzing the racemates. CONSTITUTION:The racemates of a com...

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Bibliographic Details
Main Authors SHIRAKI MASARU, YAMAZAKI YUKINAE, HOSONO KUNIAKI
Format Patent
LanguageEnglish
Published 06.03.1992
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:PURPOSE:To prepare the subject complex useful as a raw material for asymmetric organic synthesis reagents in a simple process in a good yield by asymmetrically acylating the racemates of a specific compound with a lipase and subsequently hydrolyzing the racemates. CONSTITUTION:The racemates of a compound of the formula I (R1 is alkyl, alkoxy) is asymmetrically acylated with a lipase, and the obtained ester is separated from the unreacted alcohol, followed by hydrolyzing the ester, whereby the dextro notatory optically active isomer and the levorotatory optically active isomer are obtained. The lipase is preferably a lipase originated from e.g. readily available Pseudomonas fluorescence.
Bibliography:Application Number: JP19900181088