JPH0466479B

PURPOSE:To produce lignan lactone useful as a medicine and agricultural chemical in high selectivity and yield, by reducing an acid anhydride obtained from ferulic acid as a raw material with hydrogen using a ruthenium-phosphine complex as a catalyst. CONSTITUTION:An acid anhydride expressed by form...

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Main Authors YOSHIKAWA SADAO, KAJI SHINTARO, ISHII YOICHI, SABURI MASAHIKO, IKARYA TAKAO
Format Patent
LanguageEnglish
Published 23.10.1992
Subjects
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To produce lignan lactone useful as a medicine and agricultural chemical in high selectivity and yield, by reducing an acid anhydride obtained from ferulic acid as a raw material with hydrogen using a ruthenium-phosphine complex as a catalyst. CONSTITUTION:An acid anhydride expressed by formula I (R1 and R2 are lower alkoxy or adjacent R1 together form methylenedioxy; R3 is H, OH or alkoxy; m and n are 2-3; the dotted lines are single or double bond) is reduced with hydrogen in the presence of a ruthenium-phosphine complex, e.g. RuH2(PPh3)4 (PPh3 is triphenylphosphine), etc., as a catalyst to afford the aimed lignan lactone expressed by formula II, e.g. dehydromethylretrodendrin, etc.
Bibliography:Application Number: JP19850280522