PRODUCTION OF OPTICALLY ACTIVE 2-METHYLPIPERAZINE MANDELATE AND OPTICALLY ACTIVE 2-METHYLPIPERAZINE

PURPOSE:To obtain the title new compound useful as an intermediate for optical resolution and a synthetic raw material for drugs such as antibiotics, etc. CONSTITUTION:A compound shown by the formula (* is asymmetric carbon atom). The compound is obtained by dissolving (+ or -)-2-methylpiperazine an...

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Bibliographic Details
Main Authors TAKEBAYASHI AKIKO, NOHIRA HIROYUKI, MURAKAMI NAOMICHI
Format Patent
LanguageEnglish
Published 14.12.1992
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To obtain the title new compound useful as an intermediate for optical resolution and a synthetic raw material for drugs such as antibiotics, etc. CONSTITUTION:A compound shown by the formula (* is asymmetric carbon atom). The compound is obtained by dissolving (+ or -)-2-methylpiperazine and optically active mandelic acid in a mixed solvent preferably in an acetone- containing solvent to form two kinds of diasetereomer salts and then preferentially crystallizing optically active 2-methylpiperazine mandelate as an acetone- containing diastereomer salt.
Bibliography:Application Number: JP19910163888