WS7662A, B, C AND D SUBSTANCES, THEIR DERIVATIVES, THEIR PRODUCTION AND USE

• Main Authors: OKUHARA MASAKUNI, EZAKI MASAMI, HATANAKA HIROSHI, TAKASE SHIGEHIRO, OKAMOTO MASANORI, SHIGEMATSU SHINJI, TSUJII EISAKU
• Format: Patent
• Language: English
• Published: 25.09.1991
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOUNDS OF UNKNOWN CONSTITUTION; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

NEW MATERIAL:WS7622A, B, C and D substances having the following physical and chemical properties. WS7622A substance: appearance, colorless prismatic crystal; nature, acidic; color reactions, positive to cerium sulfate reaction, iodine vapor reaction and ferric chloride reaction and negative to ninhydrin reaction, Molish reaction and Dragendorff reaction; solubility, soluble in methanol, ethanol and n-butanol, scarcely soluble in chloroform, acetone and ethyl acetate and insoluble in water and n-hexane; melting point 250-252 deg.C (decomposition); specific rotation, [alpha] =+36 deg. (c=1.0, methanol); molecular formula C47H63N9O13; elemental analysis (%) (as C47H63N9O13.2H2O), C 56.65, H 6.62, N 12.27; molecular weight, FAB-MS m/z 984 (M+Na)<+>; etc. USE:Agent for suppressing human leukocyte elastase. PREPARATION:The objective substance can be produced by culturing Streptomyces resistomycificus No.7622 (FERM BP-2306), etc.