DRUG COMPOSITION FOR ANTI-CEREBRAL EDEMA

PURPOSE:To obtain a drug composition of significantly reducing water content in the brain resulting from ischemic cerebral edema and vasogenic edema, comprising a specific peptide. CONSTITUTION:A drug composition comprising a peptide shown by formula I (X is Ile or Met; (m) and (n) are 0 or 1; A is...

Full description

Saved in:
Bibliographic Details
Main Authors SUGAWARA SHUICHI, HAYASHI HIROSHI, KIYOTA TAKAO
Format Patent
LanguageEnglish
Published 25.09.1991
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:PURPOSE:To obtain a drug composition of significantly reducing water content in the brain resulting from ischemic cerebral edema and vasogenic edema, comprising a specific peptide. CONSTITUTION:A drug composition comprising a peptide shown by formula I (X is Ile or Met; (m) and (n) are 0 or 1; A is Ser, Ser-Ser, Arg-Ser-Ser, Arg- Arg-Ser-Ser, Leu-Arg-Arg-Ser-Ser, Ser-Leu-Arg-Arg-Ser-Ser; B is Asn, Asn-Ser, Asn-Ser-Ser-Phe, Asn-Ser-Phe-Arg or Asn-Ser-Phe-Arg-Tyr), preferably a peptide shown by formula II and a peptide shown by formula III and at least one of pharmaceutically acceptable carrier, excipient and diluent. A dose of the composition is 0.1mug/kg-10mg/kg, preferably 1mug/kg-1mg/kg.
Bibliography:Application Number: JP19890297528