IMPROVEMENT OF ANTAGONIST AGAINST ANGIOTENSIN II

This invention provides phenyl and heterocyclic derivatives of the formula or a pharmaceutically acceptable salt or solvate thereof each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3; R2 is C4-C7 straight chain...

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Main Authors SHIERIRU RIN RAIFUAA, MITSUCHIERU AABUIN SUTAINBAAGU, SERIA AN HOWAITOSHITSUTO, RICHIYAADO RII SAIMON, UINSUTON SUTANREE MAASHIYARU, JIYON KEBIN RIIRU, FUARIBORUTSU MOHAMADEI
Format Patent
LanguageEnglish
Published 23.08.1991
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides phenyl and heterocyclic derivatives of the formula or a pharmaceutically acceptable salt or solvate thereof each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3; R2 is C4-C7 straight chain alkyl; each R3 is independently -OH, -COOH, or 5-tetrazolyl; each n is independently 0, 1, 2, 3, or 4; R4 is H, OH, halo, nitro, methyl, amino, acetamido, or methanesulfonamido; Q is a bond or -O-; and w is H, methyl, ethyl, or hydroxy. Their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.
Bibliography:Application Number: JP19900336864