ES-242 COMPOUND

NEW MATERIAL:ES-242 compound expressed by the formula (R1 is H, OH or acetoxy; R2 is OH or acetoxy). USE:The compound expressed by the formula has nerve cell protecting action and antagonistic action of N-methyl-D-aspartic acid receptor and is useful for prevention and treatment of nerve disorder, d...

Full description

Saved in:
Bibliographic Details
Main Authors IKEDA JUNICHI, TOKI SHINICHIRO, MATSUDA MAMORU, ANDO KATSUHIKO, KUBO KAZUHIRO, SANO HIROSHI, KAWAMOTO ISAO, NOZAWA MIKA, KODA MAYUMI
Format Patent
LanguageEnglish
Published 02.08.1991
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:NEW MATERIAL:ES-242 compound expressed by the formula (R1 is H, OH or acetoxy; R2 is OH or acetoxy). USE:The compound expressed by the formula has nerve cell protecting action and antagonistic action of N-methyl-D-aspartic acid receptor and is useful for prevention and treatment of nerve disorder, dementia, apoplexy, hypoglycemia, transient ischemic attack, epilepsy, Huntington's chorea, etc. PREPARATION:A microbial strain (e.g. verticillium sp. FERM-P 2604) belonging to the genus Verticillium is cultured, isolated and collected according to the ordinary method to provide the compound expressed by the formula. Physicochemical properties of the compound expressed by the formula are as follows: Appearance, pale yellow crystal; molecular weight, 604; molecular formula, C34H36O10; melting point, 233-237 deg.C; specific rotation, [alpha] =theta +11 deg.(C=0.46 methanol); solubility, readily soluble in methanol, acetone, etc., and insoluble in water and n-hexane.
Bibliography:Application Number: JP19900133322