PRODUCTION OF TETRAHYDRONAPHTHALENE DERIVATIVE

PURPOSE:To obtain a compound useful as a synthetic intermediate for an inhibitor of thromboxane A2 production by reacting a tetrahydronaphtalenecarboxylic acid methyl ester with imidazole in the presence of a catalyst. CONSTITUTION:A compound shown by formula I (X is aliphatic sulfonyl or aromatic s...

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Bibliographic Details
Main Authors IKETANI TAKANOBU, KAIHO SAKAE, IWASE MORIAKI
Format Patent
LanguageEnglish
Published 11.07.1991
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE:To obtain a compound useful as a synthetic intermediate for an inhibitor of thromboxane A2 production by reacting a tetrahydronaphtalenecarboxylic acid methyl ester with imidazole in the presence of a catalyst. CONSTITUTION:A compound shown by formula I (X is aliphatic sulfonyl or aromatic sulfonyl; n is 1-5; R1 is lower alkyl) or a salt thereof is reacted with imidazole in the presence of an alkali metal hydroxide and/or an alkaline earth metal hydroxide in a solvent such as dimethylformamide at 20-80 deg.C for 1-20 hours to give the objective substance shown by formula I. The amount of the catalyst used is 1.1-2mols based on 1mol of the compound shown by formula I and the amount of imidazole used is 1.1-1.5mol.
Bibliography:Application Number: JP19890302576