JPH0254839B

• Main Authors: TAKASUGI HISASHI, CHIBA TOSHUKI, TAKATANI TAKAO, TSUJI KIRYO
• Format: Patent
• Language: English
• Published: 22.11.1990
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

NEW MATERIAL:The compound of formula I {R is group of formula II [R is (protected) amino] or haloacetyl; A is CH2 or C=N-OR (R is H or 1-8C alkyl); R is OH or OR (R is H or acyl); R is carboxy or its ester; dotted line is 3-cephem or cepham; when R is group of formula I, A is C=N-OR , when R is haloacetyl, R is H and dotted line is 3-cephem, when R is group of formula I and R is H, A is C=NOH, and when R is OR , dotted line is cepham] or its salt. EXAMPLE:7-[2-( 2-Aminothiazol-4-yl )-2-methoxyiminoacetamido]-3-hydroxy-3-ce phem-4-carboxy-lic acid 4-nitrobenzyl ester hydrochloride. USE:Antibacterial agent and its intermediate. PREPARATION:The compound of formula III or its reactive derivative is made to react with the compound of formula R ACO2H or its reactive derivative.