ANTI-CATARACT EYE DROP

PURPOSE:To obtain an anti-cataract eye drop having excellent stability, increasing an amount of reduction type glutathione in crystalline lens, consisting essentially of oxidation type glutathione of a salt thereof. CONSTITUTION:An eye drop consisting essentially of oxidation type glutathione or a s...

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Bibliographic Details
Main Authors MORITA TAKAKAZU, ISO TADASHI, HIKITA TERUBUMI
Format Patent
LanguageEnglish
Published 15.02.1990
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE:To obtain an anti-cataract eye drop having excellent stability, increasing an amount of reduction type glutathione in crystalline lens, consisting essentially of oxidation type glutathione of a salt thereof. CONSTITUTION:An eye drop consisting essentially of oxidation type glutathione or a salt thereof (e.g., metallic salt such as Na or Ca or organic amine salt). When the eye drop is administered, oxidation type glutathione is changed into reduction type glutathione by action of glutathione reductase in crystalline lens and an amount of the reduction type glutathione in crystalline lens is increased to prevent opacification. The concentration of the reduction type glutathione in crystalline lens is preferably 0.5-5% and pH of the eye drop is preferably 4-7.
Bibliography:Application Number: JP19880196378