RACEMIZATION OF OPTICALLY ACTIVE ALPHA-ISOPROPYL-P-CHLOROPHENYLACETIC ACID ESTERS

PURPOSE:To readily and efficiently racemize the title compound useful as an intermediate for agricultural chemical by treating a mixture of optically active alpha-isopropyl-p-chlorophenylacetic acid esters and both antipodes with an organic strong base. CONSTITUTION:A compound expressed by the formu...

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Bibliographic Details
Main Authors YAMACHIKA HIROSHI, ODA YOSHIAKI
Format Patent
LanguageEnglish
Published 06.02.1990
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To readily and efficiently racemize the title compound useful as an intermediate for agricultural chemical by treating a mixture of optically active alpha-isopropyl-p-chlorophenylacetic acid esters and both antipodes with an organic strong base. CONSTITUTION:A compound expressed by the formula (X1-X3 are halogen or two of X1-X3 are halogen and the other is H or lower alkyl; * is asymmetric carbon) is treated with an organic strong base such as 1,8-diazabicyclo [5,4,0]7- undecene or 1,5-diazabicyclo[ 4,3,0]-5-nonene to racemize the compound expressed by the formula. The organic strong base is used normally at amount of 0.1-10 times in mol based on the compound expressed by the formula. The reaction is carried out in an inert solvent such as chloroform, methylene chloride or benzene.
Bibliography:Application Number: JP19880187461