CEPHALOSPORIN GAMMA-LACTONE COMPOUND
NEW MATERIAL:The compound of formula I (R is acyl; R is methyl substituted with electron-attracting group; n is 0 or 1). EXAMPLE:(9R,10R)-4-oxa-3,11-dioxo-5-(2-oxopropyl)-10-phenyl-acetamido- 8-thia-1- azatricyclo[7,2,0,0 , ]undeca-2(6)-ene of formula II. USE:An antibacterial agent useful for the re...
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| Main Authors | , |
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| Format | Patent |
| Language | English |
| Published |
29.11.1990
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| Subjects | |
| Online Access | Get full text |
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| Abstract | NEW MATERIAL:The compound of formula I (R is acyl; R is methyl substituted with electron-attracting group; n is 0 or 1). EXAMPLE:(9R,10R)-4-oxa-3,11-dioxo-5-(2-oxopropyl)-10-phenyl-acetamido- 8-thia-1- azatricyclo[7,2,0,0 , ]undeca-2(6)-ene of formula II. USE:An antibacterial agent useful for the remedy of diseases caused by bacteria resistant to penicillin antibiotic substances and the remedy of a penicillin- sensitive patient. PREPARATION:A compound (salt) of formula III (R ' is methylene substituted with one or two electron-attracting groups; R is M or carboxylprotecting group removable under acidic condition) is subjected to lactonization reaction under acidic condition. |
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| AbstractList | NEW MATERIAL:The compound of formula I (R is acyl; R is methyl substituted with electron-attracting group; n is 0 or 1). EXAMPLE:(9R,10R)-4-oxa-3,11-dioxo-5-(2-oxopropyl)-10-phenyl-acetamido- 8-thia-1- azatricyclo[7,2,0,0 , ]undeca-2(6)-ene of formula II. USE:An antibacterial agent useful for the remedy of diseases caused by bacteria resistant to penicillin antibiotic substances and the remedy of a penicillin- sensitive patient. PREPARATION:A compound (salt) of formula III (R ' is methylene substituted with one or two electron-attracting groups; R is M or carboxylprotecting group removable under acidic condition) is subjected to lactonization reaction under acidic condition. |
| Author | SENDAI MICHIYUKI NAGAI KATSUNORI |
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| Notes | Application Number: JP19900033241 |
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| PublicationDate | 19901129 |
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| RelatedCompanies | TAKEDA CHEM IND LTD |
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| Snippet | NEW MATERIAL:The compound of formula I (R is acyl; R is methyl substituted with electron-attracting group; n is 0 or 1).... |
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| Title | CEPHALOSPORIN GAMMA-LACTONE COMPOUND |
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