PRODUCTION OF 2-HYDROXY-4-PHENYLBUTYRIC ACID

PURPOSE:To obtain readily and in high yield the title compound to be used as an intermediate for angiotensin transferase inhibitor, etc., by heating 3- phenylpropionaldehyde cyanhydrin as raw material in the presence of conc. HCl to effect hydrolysis. CONSTITUTION:3-phenylpropionaldehyde cyanhydrin...

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Bibliographic Details
Main Authors SEGAWA HIROZO, IGARASHI RENSUKE, SHIRAKAWA HIDEO
Format Patent
LanguageEnglish
Published 11.09.1990
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To obtain readily and in high yield the title compound to be used as an intermediate for angiotensin transferase inhibitor, etc., by heating 3- phenylpropionaldehyde cyanhydrin as raw material in the presence of conc. HCl to effect hydrolysis. CONSTITUTION:3-phenylpropionaldehyde cyanhydrin as raw material is hydrolyzed in the presence of >=35% HCl (pref. conc. HCl) at 40-90 deg.C to obtain the objective 2-hydroxy-4-phenylbutyric acid. It is preferable that an oily matter formed as by-product during the hydrolysis be treated with hydrochloric acid. Or it is preferable that said oily matter be recycled to the hydrolysis process for the 3-phenylpropionaldehyde cyanhydrin. With the present method, the objective compound can be produced in a simple operation in high yield.
Bibliography:Application Number: JP19890049611