Y-09194L-B SUBSTANCE AND PRODUCTION THEREOF

• Main Authors: YAMAGUCHI YOJI, SUZUKI KENICHI, HIRAYAMA FUKUSHI, SATO TSUTOMU, MORIOKA MIKIO
• Format: Patent
• Language: English
• Published: 31.08.1990
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

NEW MATERIAL:A compound represented by the formula or acid addition salt thereof. In addition, showing following physicochemical properties; Elemental analysis (%): C 48.01, H 6.87, N 9.40, Cl 11.43; Melting point: not showing sharp melting point and gradually browning from the neighborhood of 190 deg.C; HR-FAB MS: M+H m/Z 459.26711 C24R35N4O5) Specific rotatory power: [alpha]D=-62 (C=1, methanol); Appearance: pale yellow powder; Solubility: soluble in water, metha nol and ethanol and insoluble in acetone, ethyl acetate, chloroform and n-hexane; Basic; Color reaction: positive to universal, sulfuric acid, ninhydrin, etc. USE:An antibacterial agent and an anti-neoplastic agent. PREPARATION:A strain such as Nocardiopsis sp. Y-09194L (FERM P-10461) belonging to Nocardiopsis genus is cultured, preferably under an aerobic condi tion at 30 deg.C and pH 6-8.