DRUG CONTAINING CYCLIC AMINE DERIVATIVE
NEW MATERIAL:The compound of formula I [J is phenyl, pyridyl, indanyl, indanonyl, alkyl, etc.; B is group of formula II-formula V (R is H or methyl; R is H, alkyl, acyl, phenyl, etc.; R is H, alkyl or phenyl; n is 0-10), etc.; T is N or C; Q is N, C or N-O; K is H, phenyl, arylalkyl, cinnamyl, alkyl...
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Main Authors | , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
29.06.1990
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Subjects | |
Online Access | Get full text |
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Summary: | NEW MATERIAL:The compound of formula I [J is phenyl, pyridyl, indanyl, indanonyl, alkyl, etc.; B is group of formula II-formula V (R is H or methyl; R is H, alkyl, acyl, phenyl, etc.; R is H, alkyl or phenyl; n is 0-10), etc.; T is N or C; Q is N, C or N-O; K is H, phenyl, arylalkyl, cinnamyl, alkyl, pyridylmethyl, acyl, etc.; q is 1-3] and its salt. EXAMPLE:1-Benzyl-4-[2-[(1-indanon)-2-yl]]ethylpiperidine hydrochloride. USE:It has strong acetylcholine esterase inhibiting action and choline acetyltransferase activating action and is useful for the remedy and prevention of central nervous diseases. PREPARATION:A compound of formula I wherein B is group of formula V can be produced e.g. by reacting an acid halide of formula VI with a cyclic amine derivative of formula VII in an organic solvent in the presence of a desalting agent. |
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Bibliography: | Application Number: JP19880324620 |