PRODUCTION OF THIAZOLECARBOXYLIC ACID CHLORIDES

PURPOSE:To advantageously obtain the subject compound useful as a raw material of drug or pesticide, etc., with easy control of reaction and without by- product by reacting thiazolecarboxylic acids and phosgene or trichloromethylchloroformate as raw materials. CONSTITUTION:As raw materials, thiazole...

Full description

Saved in:
Bibliographic Details
Main Authors KUWAZUKA TOSHIAKI, ISHIKAWA KATSUTOSHI, TANAKA YOSHINORI, KONO TOSHIYUKI, WATANABE SEIICHI
Format Patent
LanguageEnglish
Published 08.12.1989
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:PURPOSE:To advantageously obtain the subject compound useful as a raw material of drug or pesticide, etc., with easy control of reaction and without by- product by reacting thiazolecarboxylic acids and phosgene or trichloromethylchloroformate as raw materials. CONSTITUTION:As raw materials, thiazolecarboxylic acids expressed by formula I (R1 is H, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen or lower alkoxy; R2 is H, lower alkyl or lower alkyl substituted by halogen or lower alkoxy group) is used to be reacted with phosgene or trichloromethylchloroformate, preferably using 1.0-10.0mol, especially 1.0-5.0mol latter raw material to the compound expressed by formula I in a solvent such as benzene at normal temperature boiling point of the solvent to obtain a compound expressed by formula II. Amount of addition of solvent is 0.5-10l to 1mol compound expressed by formula I.
Bibliography:Application Number: JP19880136689