NOVEL CEPHALOSPORIN DERIVATIVE AND THIAZOLEALKENOIC ACID DERIVATIVE

• Main Authors: KOBORI TAKEO, SATO KIYOSHI, TSUNEMOTO DAIEI
• Format: Patent
• Language: English
• Published: 16.08.1989
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:The compound (salt) expressed by formula I [R is lower alkyl; R is H or 3-substituent group of cephalosporins; R is CO2H, CO2<-> or CO2R (R is salt-forming cation or protecting group). EXAMPLE:3-(3-Methyl-1,2,4-triadiazol-5-ylthiomethyl)-7-[(Z)-2-(1-,3-th iazol-4-yl)-2- butenamido]-3-cephem-4-carboxylic acid diphenylmethyl ester. USE:An antibacterial agent having broad antibacterial spectrum. PREPARATION:The compound of formula I can be produced, e.g., by reacting a thiazolealkenoic acid derivative of formula II (R is H or protecting group) with 7-amino-3-(3-methyl-1,2,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carbox ylic acid diphenylmethyl ester of formula III (Me is methyl; Ph is phenyl), etc.