JP2975949B

NEW MATERIAL:A compound shown by formula I [R is H, amino-protecting group or acyl; R is (protected) carboxyl or carboxylato; R is H, formamido, lower alkylthio, etc,; A is (substituted) 1-6C hydrocarbon or bond valent; B is (substituted) nitrogencontaining heterocyclic group, etc.; n is 0 or 1]. EX...

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Main Authors MOMOI KAISHU, WATANABE YASUO, KOMATSU MIWAKO, MORYAMA KEIKO, TANAKA KYOSHI, EGAWA HIROYUKI
Format Patent
LanguageEnglish
Published 10.11.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:A compound shown by formula I [R is H, amino-protecting group or acyl; R is (protected) carboxyl or carboxylato; R is H, formamido, lower alkylthio, etc,; A is (substituted) 1-6C hydrocarbon or bond valent; B is (substituted) nitrogencontaining heterocyclic group, etc.; n is 0 or 1]. EXAMPLE:p-Methoxybenzyl=3-[3-(2-benzyloxycarbonylaminoethyl)thio-1,2,4- thiadiazol-5-yl]thiomethyl-7-[2-(z)-methoxyimino-2-(2- triphenylmethylaminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid. USE:An antibacterial agent against gram-positive bacteria including methicilin- resistant Staphylococcus aureus. PREPARATION:A compound shown by formula II is reacted with a compound shown by the formula R OH (R is the same acyl as R ) optionally in the presence of a base.
Bibliography:Application Number: JP19890215487