JP2935740B

This invention provides phenyl and heterocyclic derivatives of the formula or a pharmaceutically acceptable salt or solvate thereof each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3; R2 is C4-C7 straight chain...

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Main Authors MITSUCHERU AAUIN SUTAINBAAGU, UINSUTON SUTANREE MAASHARU, SHERIRU RIN RAIFUAA, SERIA AN HOWAITOSHITSUTO, RICHAADO RII SAIMON, JON KEBIN RIIRU, FUARIBORUTSU MOHAMADEI
Format Patent
LanguageEnglish
Published 16.08.1999
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides phenyl and heterocyclic derivatives of the formula or a pharmaceutically acceptable salt or solvate thereof each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3; R2 is C4-C7 straight chain alkyl; each R3 is independently -OH, -COOH, or 5-tetrazolyl; each n is independently 0, 1, 2, 3, or 4; R4 is H, OH, halo, nitro, methyl, amino, acetamido, or methanesulfonamido; Q is a bond or -O-; and w is H, methyl, ethyl, or hydroxy. Their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.
Bibliography:Application Number: JP19900336864