JP2925962B

Disclosed are biphenylmethane derivatives having the formula: wherein R and R , which may be the same or different, are each a hydrogen atom, a halogen atom, a lower C1-6 alkyl group a lower C1-6 alkoxy group, a carbamoyl group or a cyano group; R stands for hydrogen or a lower C1-6 alkyl group; R i...

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Main Authors HIROSHIMA OSAMU, ISHIHARA HIROKI, HAMANO SUKEYUKI, MATSUKURA MASAYUKI, MUSHA TAKASHI, MYAKE KAZUTOSHI, MORI NOBUYUKI
Format Patent
LanguageEnglish
Published 28.07.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are biphenylmethane derivatives having the formula: wherein R and R , which may be the same or different, are each a hydrogen atom, a halogen atom, a lower C1-6 alkyl group a lower C1-6 alkoxy group, a carbamoyl group or a cyano group; R stands for hydrogen or a lower C1-6 alkyl group; R is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof; R stands for hydrogen, a halogen atom, a hydroxy group or a lower C1-6 alkoxy group, or a pharmacologically acceptable salt thereof, wherein compounds having the following formula and their pharmacologically acceptable salts are excluded: wherein R is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof and n is an integer of 1 to 2; or a pharmacologically acceptable salt thereof. Further, a process for their preparation, pharmaceutical compositions containing same and their use for the preparation of such compositions for preventing and treating hypertension and/or cardiac failure are disclosed.
Bibliography:Application Number: JP19940299389