発毛を誘導するためのＭＩＲＮＡ－４８５阻害剤の使用

• Format: Patent
• Language: Japanese
• Published: 12.01.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

本開示は、発毛を誘導し、毛髪密度を増加させ、毛包密度を増加させ、毛幹の太さを増加させ、毛髪の長さを増加させ、脱毛を予防し、脱毛を減少させるか、またはそれらを必要とする対象において上記の任意の組み合わせを行うためのｍｉＲＮＡ阻害剤の使用を含む。いくつかの態様では、対象は、全頭脱毛症、男性型脱毛症、円形脱毛症、全身性脱毛症、退行性脱毛症、抜毛癖、休止期脱毛症、成長期脱毛症、瘢痕性脱毛症（ｃｉｃａｔｒｉｃｉａｌ ａｌｏｐｅｃｉａ）、瘢痕脱毛症（ｓｃａｒｒｉｎｇ ａｌｏｐｅｃｉａ）、頭皮の薄毛、毛幹異常、感染性毛髪疾患、遺伝子疾患、及び、化学療法、ホルモンバランスの異常、真菌感染、薬剤服用、化学的毛髪処理、または加齢による抜け毛からなる群から選択される１つ以上の疾患を有する。【選択図】図１ The present disclosure includes the use of a miRNA inhibitor for inducing hair growth, increasing the hair density, increasing the follicular density, increasing the hair shaft thickness, increasing hair length, preventing hair loss, reducing hair loss, or any combination thereof in a subject in need thereof. In some aspects, the subject has one or more disorders selected from the group consisting of alopecia greata, androgenic alopecia, alopecia areata, alopecia universalis, involutional alopecia, trichotillomania, telogen effluvium, anagen effluvium, cicatricial, alopecia, scarring alopecia, scalp thinning, hair shaft abnormalities, infectious hair disorders, genetic disorders, and hair loss due to chemotherapy, hormonal imbalance, fungal infection, medication intake, chemical hair treatment, or aging.