METHODS OF TREATMENT WITH ANTI-FACTOR XI/XIA ANTIBODIES

To provide methods of preventing, treating, managing, or reducing the risk of stroke or thromboembolism.SOLUTION: This method comprises the step of administering, to a subject afflicted with end stage renal disease, an effective amount of a pharmaceutical composition comprising an antibody or antige...

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Bibliographic Details
Main Authors MARTIN LEFKOWITZ, CAROLA FRIEDMAN, YASSER KHDER
Format Patent
LanguageEnglish
Japanese
Published 27.08.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide methods of preventing, treating, managing, or reducing the risk of stroke or thromboembolism.SOLUTION: This method comprises the step of administering, to a subject afflicted with end stage renal disease, an effective amount of a pharmaceutical composition comprising an antibody or antigen-binding fragment that binds within the catalytic domain of Factor XI ("FXI") and/or activated FXI ("FXIa").SELECTED DRAWING: None 【課題】脳卒中または血栓塞栓症の危険性を防止、処置、または管理、または低減する方法を提供する。【解決手段】末期腎疾患に罹患している対象へと、第ＸＩ因子（「ＦＸＩ」）および／または活性化ＦＸＩ（「ＦＸＩａ」）の触媒ドメイン内に結合する抗体または抗原結合性断片を含む、有効量の医薬組成物を投与するステップを含む方法である。【選択図】なし
Bibliography:Application Number: JP20240091065