BISPECIFIC T-CELL ENGAGING ANTIBODY CONSTRUCTS

• Main Authors: PAMELA BOGNER, PATRICK HOFFMANN, TOBIAS RAUM, MARKUS MUENZ, PETER KUFER, MATTHIAS FRIEDRICH, BENNO RATTEL, CORNELIUS POMPE, ANDREAS WOLF, JOHANNES BROZY
• Format: Patent
• Language: English; Japanese
• Published: 17.07.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or Macaca CD3ε chain and a third domain, which is of the specific Fc modality.SOLUTION: An antibody construct comprises at least three domains. A first domain binds to a target cell surface antigen. A second domain binds to an extracellular epitope of the human and/or Macaca CD3ε chain. A third domain comprises two polypeptide monomers, each comprising a hinge, a CH2 and a CH3 domain, where the two polypeptide monomers are fused to each other via a peptide linker.SELECTED DRAWING: None 【課題】標的細胞表面抗原に結合する第１のドメイン、ヒトおよび／またはマカクＣＤ３ε鎖の細胞外エピトープに結合する第2のドメイン、ならびに特定のFc様式である第３のドメインを含むことによって特徴づけられる、特定のＦｃ様式の二重特異性抗体コンストラクトの提供。【解決手段】少なくとも３つのドメインを含み、第１のドメインが標的細胞表面抗原に結合し、第２のドメインがヒトおよび／またはマカクＣＤ３ε鎖の細胞外エピトープに結合し、かつ第3のドメインが、ヒンジ、ＣＨ２、およびＣＨ３ドメインを各々が含む２つのポリペプチド単量体を含み、２つのポリペプチド単量体がペプチドリンカーを通じて相互に融合されている、抗体コンストラクト。【選択図】なし