PHARMACEUTICAL COMPOSITION

• Main Authors: MATSUDA SATOSHI, MENJO YASUHIRO, HANARI YASUTAKA, TANAKA HIROTAKA, FUJITA SHIGEKAZU, TAKUWA MASAKUNI, URUSHIJIMA TATSUYA, FUJIWARA HIDETO, SUGA KEIZO, OTATSU KAZUHIRO, YAMABE HOKUTO
• Format: Patent
• Language: English; Japanese
• Published: 24.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide medicinal use of a novel benzoazepine compound or a salt thereof having vasopressin V1a and V2 antagonism.SOLUTION: A pharmaceutical composition comprises a compound represented by the formula (1) or a salt thereof as an active ingredient. [In the formula, R1 represents optionally substituted C1-6 alkyl or the like; L represents -C(=O)-NH- or the like; the ring A1 represents a hydrocarbon ring or the like; and the ring A2 represents a hydrocarbon ring or the like; where the rings A1 and A2 may each have at least one substituent.]SELECTED DRAWING: None 【課題】本発明は、バソプレシンＶ１ａ及びＶ２拮抗作用を有する新規なベンゾアゼピン化合物又はその塩の医薬用途を提供する。【解決手段】式（１）で表される化合物またはその塩を有効成分とする医薬組成物JPEG2024071549000104.jpg5956［式中、Ｒ１は、置換されていてもよいＣ１－６アルキル等を示す；Ｌは、－Ｃ（＝Ｏ）－ＮＨ－等を示す；環Ａ１は、炭化水素環等を示す；環Ａ２は、炭化水素環等を示す；環Ａ１及びＡ２はそれぞれ、少なくとも１個の置換基を有していてもよい。］。【選択図】なし