PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS

To provide a composition having a sufficiently selective KRAS inhibitory effect against HRAS and NRAS.SOLUTION: The present disclosure provides a pharmaceutical composition for treating or preventing, for example, a cell proliferative disease, the pharmaceutical composition containing as an active i...

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Main Authors KAGE MIRAI, HASHIMOTO SATORU, KOTAKE TOMOYA, MORITA YUYA, WAKAMIYA YUMA, HAYASHI RYUJI, TAMIYA MINORU, KAWADA HATSUO, TAKANO KOJI
Format Patent
LanguageEnglish
Japanese
Published 21.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a composition having a sufficiently selective KRAS inhibitory effect against HRAS and NRAS.SOLUTION: The present disclosure provides a pharmaceutical composition for treating or preventing, for example, a cell proliferative disease, the pharmaceutical composition containing as an active ingredient a cyclic compound that selectively inhibits KRAS, represented by the formula (1).SELECTED DRAWING: Figure 1 【課題】HRASおよびNRASに対して十分に選択的なKRAS阻害作用を有する化合物を提供する。【解決手段】本開示は、例えば、細胞増殖性疾患の治療又は予防用医薬組成物であって、KRASを選択的に阻害する下記式（１）で表される環状化合物を有効成分として含有する医薬組成物を開示する。TIFF2024069167001336.tif88148【選択図】図１
Bibliography:Application Number: JP20230190611