PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME

• Main Authors: CHUN BYOUNG-KWON, DEVAN NADUTHAMBI, PETR JANSA, MACKMAN RICHARD L, DANIEL H BYUN, NEIL H SQUIRES, MICHAEL O CLARKE
• Format: Patent
• Language: English; Japanese
• Published: 10.05.2024
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

To provide methods for treating diseases.SOLUTION: The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides, and compositions, methods and kits thereof. Such compounds can be useful for treating virus infections including human immunodeficiency virus. The compounds have the following formula (I). Provided herein are compounds functioning as antiviral agents (in some embodiments, as anti-HIV agents), pharmaceutical compositions comprising such a compound and optionally in combination with one or more (e.g., two, three or four) additional therapeutic agents, and methods for using such compounds and compositions. Embodiment of every disclosed compound includes pharmaceutically acceptable salts and stereoisomers thereof or a mixture of the stereoisomers.SELECTED DRAWING: None 【課題】疾患を処置する方法を提供する。【解決手段】４'－Ｃ－置換－２－ハロ－２'－デオキシアデノシドヌクレオシドのプロドラッグ、及びそれらの組成物、方法、及びキットを提供する。そのような化合物は、ヒト免疫不全ウイルスを含むウイルス感染症を治療するのに有用であり得る。化合物は、以下の式（Ｉ）を有する。本明細書では、抗ウイルス剤として機能する化合物（いくつかの実施形態では、抗ＨＩＶ剤）、そのような化合物を含み、任意選択で１つ以上（例えば、２つ、３つ、又は４つ）の追加の治療薬と組み合わせた医薬組成物、そのような化合物及び組成物を使用する方法が提供される。本開示の全ての化合物の実施形態は、その任意の薬学的に許容される塩、その立体異性体、又はその立体異性体の混合物を含む。JPEG2024063164000272.jpg4364【選択図】なし