THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER

• Main Authors: TUERECI OEZLEM, SAHIN UGUR
• Format: Patent
• Language: English; Japanese
• Published: 23.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide a therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, in particular cancer diseases such as gastroesophageal cancer.SOLUTION: A method comprises administering an antibody having the ability of binding to CLDN18.2 so as to provide a serum level of at least 40 μg/ml.SELECTED DRAWING: None 【課題】ＣＬＤＮ１８．２を発現する細胞に関連する疾患、特に胃食道癌などの癌疾患を有効に治療および／または予防するための治療法を提供する。【解決手段】ＣＬＤＮ１８．２に結合する能力を有する抗体を少なくとも４０μｇ／ｍｌの血清レベルを提供するように投与することを含む方法とする。【選択図】なし