RECOMBINANT HUMANIZED COLLAGEN AND APPLICATION THEREOF

• Main Authors: ZENG HUILING, REN JIE, SHEN HAIYANG, ZHANG CHIJIAN, ZHANG ZHITING, LIU QIYIN, HE TINGGANG, AI YONG, HU LIYUN
• Format: Patent
• Language: English; Japanese
• Published: 10.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; SPIRITS; VINEGAR; WINE

To provide recombinant humanized collagen and application thereof.SOLUTION: The recombinant humanized collagen comprises a leader peptide and at least one basic repeating unit, where the basic repeating unit comprises an amino acid sequence as shown in SEQ ID NO:1. The invention further provides a method for preparing the recombinant humanized collagen. The recombinant humanized collagen of the invention has good solubility, stability, biological activity and adhesiveness, and low immunogenicity and high safety, featured by low preparation cost, high efficiency, matured technology and easy operation, as well as prospect of important applications.SELECTED DRAWING: Figure 2 【課題】本発明は、組換えヒト型化コラーゲンおよびその応用を提供する。【解決手段】前記組換えヒト型化コラーゲンは、リーダーペプチドおよび少なくとも１つの基本繰り返し単位を含み、前記基本繰り返し単位は、ＳＥＱ ＩＤ Ｎｏ．１で示されるアミノ酸配列を含む。本発明は、前記組換えヒト型化コラーゲンの調製方法を更に提供する。本発明に記載の組換えヒト型化コラーゲンは、良好な溶解性、安定性、生物活性および接着性を有し、免疫原性が低くてより安全であり、調製コストが低く、効率が高く、技術が成熟し、操作しやすく、重要な応用の見通しを有している。【選択図】図２