TRYPTOPHAN SELECTIVE MODIFIER, AND METHOD FOR PRODUCING Trp-S BOND-CONTAINING COMPOUND USING THE SAME

To provide means capable of chemically modifying biomolecules such as peptides and proteins with high efficiency, without employing the harsh reaction conditions like conventional techniques.SOLUTION: A compound represented by chemical formula 1 or a salt thereof is employed as a tryptophan-selectiv...

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Bibliographic Details
Main Authors TAGUCHI AKIHIRO, CUI YAN, HAYASHI YOSHIO, SHIDA HAYATE
Format Patent
LanguageEnglish
Japanese
Published 09.04.2024
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:To provide means capable of chemically modifying biomolecules such as peptides and proteins with high efficiency, without employing the harsh reaction conditions like conventional techniques.SOLUTION: A compound represented by chemical formula 1 or a salt thereof is employed as a tryptophan-selective modifier to selectively modify tryptophan residues in molecules, which contain the tryptophan residues, in the presence of a compound containing a thioether group. Each symbol in chemical formula 1 is as defined in the specifications.SELECTED DRAWING: Figure 4 【課題】従来法のような過酷な反応条件を用いずとも、高い効率でペプチドやタンパク質のような生体分子の化学修飾を達成しうる手段を提供する。【解決手段】下記化学式１で表される化合物またはその塩を、チオエーテル基を有する化合物の存在下で、トリプトファン残基を含有する分子における前記トリプトファン残基を選択的に修飾するためのトリプトファン選択的修飾剤として用いる：JPEG2024048806000036.jpg26161化学式１中の符号は、明細書において定義されている通りである。【選択図】図４
Bibliography:Application Number: JP20220154918