BISPECIFIC BINDING PROTEINS AND USES THEREOF

• Main Authors: KRISTEN POLLIZZI, GAO CHANGSHOU, BRIAN LOBO, DARREN SCHOFIELD, GIANLUCA CARLESSO, PRAKASH MANIKWAR, JONATHAN SEAMAN, CLAIRE LOUISE DOBSON, MICHAEL OBERST, RONALD HERBST, YARIV MAZOR, GODFREY RAINEY, SCOTT A HAMMOND, STACEY DRABIC, SIMON DOVEDI, SRINATH KASTURIRANGAN, MICHELLE MORROW
• Format: Patent
• Language: English; Japanese
• Published: 02.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide bispecific binding proteins and methods of using the same.SOLUTION: A protein comprises: a first binding domain (BD1) that binds to a first epitope; a second binding domain (BD2) that binds to a second epitope; and an Fc region comprising CH2 and CH3 domains; where the Fc region comprises BD2 at a solvent exposed loop in the CH2 domain, the CH3 domain, or at the interface between the CH2 and CH3 domains; and where the protein is bivalent for binding to each of the first and second epitopes. The disclosure also provides specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides methods of inducing an immune response in a subject, and methods of treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules, and/or compositions to the subject.SELECTED DRAWING: Figure 1-1 【課題】二重特異性結合タンパク質およびその使用方法を提供する。【解決手段】第１のエピトープに結合する第１の結合ドメイン（ＢＤ１）と、第２のエピトープに結合する第２の結合ドメイン（ＢＤ２）と、ＣＨ２およびＣＨ３ドメインを含むＦｃ領域とを含むタンパク質であって、Ｆｃ領域は、ＣＨ２ドメイン、ＣＨ３ドメイン、またはＣＨ２およびＣＨ３ドメインの境界面における溶媒曝露ループにＢＤ２を含み、前記タンパク質は、第１および第２のエピトープの各々に結合するために二価である、タンパク質を提供する。本開示は、標的タンパク質に結合する、抗体などの特異性結合タンパク質も提供する。本開示は、対象において免疫応答を誘導する方法、ならびにタンパク質、核酸分子および／または組成物を対象に投与することにより、対象において癌を治療または予防する方法も提供する。【選択図】図１－１