USE OF FCRN ANTAGONISTS FOR TREATMENT OF GENERALIZED MYASTHENIA GRAVIS

To provide a pharmaceutical composition for treating generalized myasthenia gravis in a subject.SOLUTION: Provided is a pharmaceutical composition for use in the treatment of generalized myasthenia gravis (gMG) in a human subject, comprising an FcRn antagonist, the FcRn antagonist consisting of a va...

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Bibliographic Details
Main Authors PETER ULRICHTS, ANTONIO GUGLIETTA, NICOLAS LEUPIN, JOHANNES DE HAARD, TORSTEN DREIER
Format Patent
LanguageEnglish
Japanese
Published 27.03.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a pharmaceutical composition for treating generalized myasthenia gravis in a subject.SOLUTION: Provided is a pharmaceutical composition for use in the treatment of generalized myasthenia gravis (gMG) in a human subject, comprising an FcRn antagonist, the FcRn antagonist consisting of a variant IgG Fc region, the variant Fc region consisting of two Fc domains forming a homodimer, the Fc domain of the variant IgG Fc region comprising a specific amino acid sequence.SELECTED DRAWING: None 【課題】対象において全身型重症筋無力症を治療するための医薬組成物を提供する。【解決手段】FcRnアンタゴニストを含む、ヒト対象の全身型重症筋無力症(gMG)の治療における使用のための医薬組成物であって、該FcRnアンタゴニストが、バリアントIgG Fc領域からなり、該バリアントFc領域が、ホモ二量体を形成する2つのFcドメインからなり、該バリアントIgG Fc領域の該Fcドメインが特定のアミノ酸配列を含む、前記医薬組成物とする。【選択図】なし
Bibliography:Application Number: JP20240004278