ORAL SOLID PREPARATIONS

To provide an oral solid preparation with improved storage stability, comprising a DAAO inhibitor, which is a pyridazinone derivative.SOLUTION: Disclosed herein are oral solid preparations comprising a D-amino acid oxidase (DAAO) inhibitor, a low-substituted hydroxypropyl cellulose (L-HPC), and an a...

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Bibliographic Details
Main Authors HAWAKABE YOSHIYUKI, SUEHARA TETSUYA, HARADA KAZUKI
Format Patent
LanguageEnglish
Japanese
Published 25.03.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide an oral solid preparation with improved storage stability, comprising a DAAO inhibitor, which is a pyridazinone derivative.SOLUTION: Disclosed herein are oral solid preparations comprising a D-amino acid oxidase (DAAO) inhibitor, a low-substituted hydroxypropyl cellulose (L-HPC), and an additive, wherein the DAAO inhibitor is a pyridazinone derivative, methods for producing the same, and methods of using the same in the prevention or treatment of diseases preventable or treatable using the DAAO inhibitors.SELECTED DRAWING: None 【課題】ピリダジノン誘導体であるＤＡＡＯ阻害剤の、より保存安定性のある経口固体製剤を提供すること。【解決手段】本明細書では、Ｄ－アミノ酸オキシダーゼ（ＤＡＡＯ）阻害剤、低置換ヒドロキシプロピルセルロース（Ｌ－ＨＰＣ）、および添加剤を含む経口固体製剤であって、ＤＡＡＯ阻害剤がピラダジノン誘導体である経口固体剤形、これを生成するための方法、ならびにＤＡＡＯ阻害剤を使用して予防可能なまたは処置可能な疾患の予防または処置でこれを使用する方法が開示される。【選択図】なし
Bibliography:Application Number: JP20240019392